Road favorites have dominated NFL betting this season, winning outright in 72.2% of games, and Week 10 continues that trend with several notable away teams favored. The Jacksonville Jaguars lead the pack as the biggest road favorite of the year, laying 10.5 points at the Tennessee Titans on Sunday.
The Jaguars’ status as heavy favorites follows their active moves at the trade deadline, while the Titans have been sellers. Jacksonville’s spread is the widest for an away team this season, reflecting confidence from sportsbooks and bettors alike. This matchup stands out as a key point for those crafting their Week 10 NFL picks.
Sunday’s slate includes seven road favorites, such as the Buffalo Bills at the New York Jets (-7.5), the Kansas City Chiefs at the Atlanta Falcons (-3.5), and the San Francisco 49ers at the Dallas Cowboys (-3.5). SportsLine’s model, which has simulated every NFL game 10,000 times this season, projects the Bills covering their spread against the Jets 59% of the time. The model’s success has translated into over $5,000 profit for $100 bettors since its launch, and it has assembled a five-team parlay for Week 10 paying 20-1. One leg of that parlay backs the Over 37.5 points in the Indianapolis Colts vs. Miami Dolphins game, with a projected combined score of 46 points.
Among the NFL experts contributing to betting advice, Larry Hartstein is backing the 49ers to cover against Dallas. He cited the Cowboys’ recent home losses and defensive struggles, adding that San Francisco could win by at least a touchdown. The Cowboys have key players out for Sunday, including tight end Jake Ferguson, running back Ty Goodson, and safety P.J. Locke.
The Bengals-Steelers game on Sunday Night Football also draws attention. Both teams hold 6-2 records, with the Bengals favored by 3.5 points after recent offensive improvements. Analyst R.J. White pointed to Cincinnati’s switch away from under-center play since Week 7, which produced 15 touchdowns in five halves and overtime. He expects the Bengals to score 30 or more points and leans toward a Bengals -6 line, though the official spread remains at 3.5. The over/under is set at 49.5 points.
Monday Night Football pits the Baltimore Ravens against the Los Angeles Rams. Baltimore has lost four straight, while the Rams have dropped 11 consecutive games dating back to last season. Ravens quarterback Jacoby Brissett is expected to start, and SportsLine’s AI model supports a prop bet on Brissett exceeding 214.5 passing yards. The game also carries weight for Jim Harbaugh, who faces the team that fired his brother.
For those interested in daily fantasy sports, SportsLine’s DFS Optimizer highlights Panthers running back Chuba Hubbard and Vikings wide receiver Justin Jefferson as top picks for Sunday’s main slate. The optimizer combines advanced data projections with input from DFS professional Mike McClure to help players build competitive lineups on DraftKings and FanDuel.
The trend of backing road favorites in Week 10 is clear across betting markets and expert analysis. With teams like Jacksonville, Buffalo, and San Francisco favored away from home, bettors and DFS players have several strong options to consider. SportsLine’s resources offer picks and projections for every game, alongside tools like NFL player props and fantasy rankings, including a top-25 Fantasy running back projection for Saints’ Audric Estime this week.
This weekend’s NFL betting landscape reflects a growing emphasis on road favorites, with the Jaguars’ 10.5-point spread at Tennessee the most significant marker of that trend so far in 2026.
According to CBS.
