Drew Mestemaker and the Oklahoma State Cowboys will face the West Virginia Mountaineers at 6 p.m. Central Time on Saturday, September 26, at Milan Puskar Stadium in Morgantown, West Virginia. The game will be broadcast live on FS1, with Eric Collins and Spencer Tillman providing commentary. Fans can also stream the matchup through Fubo.
Oklahoma State enters Week 4 with a 2-1 record after a dominant 59-0 win over Murray State last weekend. Quarterback Drew Mestemaker has been effective behind an offensive line that has allowed only one sack in the past two weeks. Mestemaker could exploit West Virginia’s pass defense, which ranks near the bottom of the Big 12, surrendering 246.7 yards per game. According to The Oklahoman’s Ben Hutchens, Mestemaker is poised for "a third consecutive 300-yard passing day," which would help the Cowboys secure a victory.
West Virginia, meanwhile, is 3-0 coming off an upset win against No. 25 Virginia, 38-27, on the road. The Mountaineers rely heavily on their ground game, rushing for 247 yards against Virginia with an average of 4.8 yards per carry. Michael Hawkins Jr., a former Oklahoma quarterback, leads the Mountaineers with 477 passing yards, five touchdowns, and zero interceptions this season. He also tops the team with 322 rushing yards and six rushing touchdowns, making West Virginia’s offense a dual threat.
The Mountaineers’ strategy likely involves controlling possession through their rushing attack to limit Oklahoma State’s offensive opportunities. West Virginia's ability to keep the ball on the ground could challenge the Cowboys’ defense, which will need to contain Hawkins’s running threat to prevent extended drives.
BetMGM’s odds as of September 18 give West Virginia a slight advantage with a two-point spread and a moneyline of -125. Oklahoma State is listed at +105 on the moneyline, with the over/under set at 60.5 points. The Oklahoman’s prediction favors Oklahoma State in a 35-30 win, citing Mestemaker’s passing against West Virginia’s vulnerable pass defense, despite the pressure the Cowboys’ defense will face from the Mountaineers’ rushing attack.
The game is part of Week 4’s Big 12 schedule, which includes several games kicking off earlier that day, such as Sam Houston State at Texas Tech and Colorado at Baylor at 11 a.m. Central Time. Oklahoma State’s road game at West Virginia is slated for the evening slot, sharing airtime with Arizona at Washington State on CBS.
Oklahoma State’s 2026 schedule shows the Cowboys will host UCF on October 10 and visit Houston and Iowa State in the following weeks. West Virginia’s schedule includes a trip to Iowa State on October 3 and a home game against Arizona on October 10.
The Week 4 matchup pits two unbeaten teams—West Virginia at 3-0 and Oklahoma State at 2-1—each looking to build momentum early in the season. The game will test Oklahoma State’s passing attack against West Virginia’s rushing offense, with both teams hoping to gain an edge as Big 12 play approaches.
According to Yahoo Sports.